Burden of Egypt
Isa 19:1 The burden of Egypt. Behold, the LORD rideth upon a swift cloud, and shall come into Egypt: and the idols of Egypt shall be moved at his presence, and the heart of Egypt shall melt in the midst of it.
God's judgement would come to Egypt. For sure this happened in Exodus when the death angel came as a cloud killing the first born of Egypt,
Exo 12:12 For I will pass through the land of Egypt this night, and will smite all the firstborn in the land of Egypt, both man and beast; and against all the gods of Egypt I will execute judgment: I am the LORD.
Isa 19:2 And I will set the Egyptians against the Egyptians: and they shall fight every one against his brother, and every one against his neighbour; city against city, and kingdom against kingdom.
There would be rebellion and civil war within Egypt. The nation would be divided into twelve kingdoms.The kingdoms would war, one with another.
Isa 19:3 And the spirit of Egypt shall fail in the midst thereof; and I will destroy the counsel thereof: and they shall seek to the idols, and to the charmers, and to them that have familiar spirits, and to the wizards.
Egypt is a type of the world. The spirit of Egypt was worldly knowledge; worship of men and idols. Their wisdom would fail them, and they would seek the occult for wisdom and guidance, turning from human reasoning to the darkness of false idols; to charmers and seers, familiar spirits that had watched a family for generations and to wizards, that conjured up spirits and cast spells. This was and is a great sin.
Remember when Moses came to deliver Israel from Egypt, that the plagues all represented one of their false gods. God showed that he was above all of their gods, and greater than their sorceries. Goodness is greater than evil. (Exo 7-12)
Isa 19:4 And the Egyptians will I give over into the hand of a cruel lord; and a fierce king shall rule over them, saith the Lord, the LORD of hosts.
Nebuchadnezzar, who first conquered and ravaged Egypt, B.C. 573, and the following year; and then, not only his successors, but Cambyses, (who invaded Egypt, B.C. 526,) the son of Cyrus, and the whole succession of Persian kings till the time of Alexander, who were in general hard masters, and grievously oppressed the country. (Treasury of Scripture Knowledge)