Isa 13:12 I will make a man more precious than fine gold; even a man than the golden wedge of Ophir.
This is a continuation of the things that will come against Babylon. Men will be precious, perhaps because there will be so few left alive?
Isa 4:1 And in that day seven women shall take hold of one man, saying, We will eat our own bread, and wear our own apparel: only let us be called by thy name, to take away our reproach.
Isa 13:13 Therefore I will shake the heavens, and the earth shall remove out of her place, in the wrath of the LORD of hosts, and in the day of his fierce anger.
The wrath of the LORD is always against unrighteousness and sin. The LORD is slow to anger, but when it is time to judge the nations, it is a terrible time.
Isa 13:14 And it shall be as the chased roe, and as a sheep that no man taketh up: they shall every man turn to his own people, and flee every one into his own land.
Babylon and it's might will flee as frightened week animals.
Isa 13:15 Every one that is found shall be thrust through; and every one that is joined unto them shall fall by the sword.
A terrible time for Babylon as the Persians make war.
Isa 13:16 Their children also shall be dashed to pieces before their eyes; their houses shall be spoiled, and their wives ravished.
This occurred after the death of Alexander the great.